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Construction of hybrid DNAs@CP for the rapid synchronous sensing of multiplex microRNAs based on experimental studies and molecular simulation.
Yang, Zi-Chuan; Wang, Tao-Rui; Li, Rong-Tian; Chen, Ting-Wei; Fan, Yue; Jiang, Wei-Hua; Li, Min-Min; Chen, Jin-Xiang.
Afiliação
  • Yang ZC; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Wang TR; Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, PR China.
  • Li RT; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Chen TW; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Fan Y; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Jiang WH; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Li MM; Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. Electronic address: limm269@126.com.
  • Chen JX; Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: jxchen@smu.edu.cn.
J Inorg Biochem ; 208: 111076, 2020 07.
Article em En | MEDLINE | ID: mdl-32304915
ABSTRACT
A water stable one-dimensional (1D) ladder-shaped coordination polymer (CP) has been synthesized and exhibits a strong affinity to two fluorescein-tagged single-stranded probe DNAs (P-DNAs), giving a sensing platform of P-DNAs@1. Such a hybrid sensing platform is capable of simultaneous detection of breast cancer related microRNA-221 (miRNA-221) and miRNA-222 in a specific and synchronous manner, without observable cross-reactions, as supported by experimental evidences. The interaction mode and the electronic energy between CP 1 with nucleic acid were confirmed by molecular simulation and the universal force field (UFF).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / MicroRNAs / Complexos de Coordenação / Simulação de Dinâmica Molecular Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / MicroRNAs / Complexos de Coordenação / Simulação de Dinâmica Molecular Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article