Multichannel bacterial discrimination based on recognition and disintegration disparity of short antimicrobial peptides.
Anal Biochem
; 600: 113764, 2020 07 01.
Article
em En
| MEDLINE
| ID: mdl-32360199
ABSTRACT
In this paper, we present a facile and rapid multichannel approach for the simultaneous detection and discrimination of multiple bacterial species. The proposed assay employed four short antimicrobial peptides (SAMPs) for recognition due to their disparity in antibacterial activity against different bacterial strains, and utilized fluorescence measurements to explicate the bacterial recognition and disintegration disparity of the SAMPs. Then, linear discriminant analysis (LDA) was used to effectively discriminate and classify the observed characteristic fluorescence patterns of SAMPs towards target bacteria, exhibiting excellent bacterial discrimination and classification accuracy. This is the first report on the use of SAMPs as recognition units for simultaneous multiple bacterial detection and discrimination. The presented approach was simple, fast, highly repeatable, and required no labelling processes. According to the corresponding LDA discriminant results, six different target bacterial species could be effectively identified and discriminated within 30 min.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
3_ND
Problema de saúde:
1_desigualdade_iniquidade
/
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Peptídeos Catiônicos Antimicrobianos
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Aspecto:
Equity_inequality
Idioma:
En
Revista:
Anal Biochem
Ano de publicação:
2020
Tipo de documento:
Article