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APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.
Makkar, Steve R; Lipnicki, Darren M; Crawford, John D; Kochan, Nicole A; Castro-Costa, Erico; Lima-Costa, Maria Fernanda; Diniz, Breno Satler; Brayne, Carol; Stephan, Blossom; Matthews, Fiona; Llibre-Rodriguez, Juan J; Llibre-Guerra, Jorge J; Valhuerdi-Cepero, Adolfo J; Lipton, Richard B; Katz, Mindy J; Wang, Cuiling; Ritchie, Karen; Carles, Sophie; Carriere, Isabelle; Scarmeas, Nikolaos; Yannakoulia, Mary; Kosmidis, Mary; Lam, Linda; Chan, Wai Chi; Fung, Ada; Guaita, Antonio; Vaccaro, Roberta; Davin, Annalisa; Kim, Ki Woong; Han, Ji Won; Suh, Seung Wan; Riedel-Heller, Steffi G; Roehr, Susanne; Pabst, Alexander; Ganguli, Mary; Hughes, Tiffany F; Snitz, Beth; Anstey, Kaarin J; Cherbuin, Nicolas; Easteal, Simon; Haan, Mary N; Aiello, Allison E; Dang, Kristina; Pin Ng, Tze; Gao, Qi; Zin Nyunt, Ma Shwe; Brodaty, Henry; Trollor, Julian N; Leung, Yvonne; Lo, Jessica W.
Afiliação
  • Makkar SR; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
  • Lipnicki DM; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
  • Crawford JD; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
  • Kochan NA; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
  • Castro-Costa E; Instituto René Rachou da Fundaçaõ Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Lima-Costa MF; Instituto René Rachou da Fundaçaõ Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Diniz BS; Department of Psychiatry, Faculty of Medicine University Toronto, Ontario, Canada.
  • Brayne C; Geriatric Psychiatry Division, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Stephan B; Department of Public Health and Primary Care, Cambridge University, UK.
  • Matthews F; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
  • Llibre-Rodriguez JJ; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
  • Llibre-Guerra JJ; Finlay-Albarrán Faculty of Medical Sciences, Medical University of Havana, Cuba.
  • Valhuerdi-Cepero AJ; Institute of Neurology and Neurosurgery, Havana, Cuba.
  • Lipton RB; Memory and Aging Center, UCSF, San Francisco, California.
  • Katz MJ; Medical University of Matanzas, Matanzas, Cuba.
  • Wang C; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.
  • Ritchie K; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.
  • Carles S; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.
  • Carriere I; Inserm, U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France.
  • Scarmeas N; Université de Montpellier, Montpellier, France.
  • Yannakoulia M; Inserm, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France.
  • Kosmidis M; Paris Descartes University, Paris, France.
  • Lam L; Inserm, U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France.
  • Chan WC; Université de Montpellier, Montpellier, France.
  • Fung A; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
  • Guaita A; Taub Institute for Research in Alzheimer's disease and the Aging Brain, Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York city, New York.
  • Vaccaro R; Department of Nutrition and Dietetics (M.Y.), Harokopio University, Athens, Greece.
  • Davin A; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Kim KW; Department of Psychiatry, The Chinese University of Hong Kong.
  • Han JW; Department of Psychiatry, The Chinese University of Hong Kong.
  • Suh SW; Department of Applied Social Sciences, The Hong Kong Polytechnic University.
  • Riedel-Heller SG; Golgi Cenci Foundation, Abbiategrasso, Italy.
  • Roehr S; Golgi Cenci Foundation, Abbiategrasso, Italy.
  • Pabst A; Golgi Cenci Foundation, Abbiategrasso, Italy.
  • Ganguli M; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Hughes TF; Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.
  • Snitz B; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Anstey KJ; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Cherbuin N; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
  • Easteal S; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
  • Haan MN; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
  • Aiello AE; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Dang K; Department of Sociology, Anthropology, and Gerontology, Youngstown State University, Youngstown, Ohio.
  • Pin Ng T; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Gao Q; Neuroscience Research Australia, Sydney, Australia.
  • Zin Nyunt MS; Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, The Australian National University, Canberra, Australia.
  • Brodaty H; Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, The Australian National University, Canberra, Australia.
  • Trollor JN; John Curtin School of Medical Research, College of Health and Medicine, The Australian National University, Canberra, Australia.
  • Leung Y; University of California, School of Medicine, Department of Epidemiology and Biostatistics, San Francisco, California.
  • Lo JW; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina.
J Gerontol A Biol Sci Med Sci ; 75(10): 1863-1873, 2020 09 25.
Article em En | MEDLINE | ID: mdl-32396611
ABSTRACT
We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Envelhecimento / Apolipoproteína E4 / Disfunção Cognitiva Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Gerontol A Biol Sci Med Sci Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Envelhecimento / Apolipoproteína E4 / Disfunção Cognitiva Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Gerontol A Biol Sci Med Sci Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália