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A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells.
Usta, Diren; Sigaud, Romain; Buhl, Juliane L; Selt, Florian; Marquardt, Viktoria; Pauck, David; Jansen, Jennifer; Pusch, Stefan; Ecker, Jonas; Hielscher, Thomas; Vollmer, Johanna; Sommerkamp, Alexander C; Rubner, Tobias; Hargrave, Darren; van Tilburg, Cornelis M; Pfister, Stefan M; Jones, David T W; Remke, Marc; Brummer, Tilman; Witt, Olaf; Milde, Till.
Afiliação
  • Usta D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Sigaud R; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Buhl JL; KiTZ Clinical Trial Unit (ZIPO), Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Selt F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Marquardt V; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Pauck D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Jansen J; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Pusch S; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Ecker J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Hielscher T; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Vollmer J; KiTZ Clinical Trial Unit (ZIPO), Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sommerkamp AC; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Germany, and Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rubner T; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Germany, and Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hargrave D; Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany, Centre for Biological Signalling Studies BIOSS, University of Freiburg, Comprehensive Cancer Center Freiburg (CCCF) and German Consortium for Translational Cancer Research (DKTK)
  • van Tilburg CM; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Pfister SM; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Remke M; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Brummer T; KiTZ Clinical Trial Unit (ZIPO), Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Witt O; Division of Biostatistics, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Mol Cancer Ther ; 19(8): 1736-1750, 2020 08.
Article em En | MEDLINE | ID: mdl-32451331
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Genes Reporter / Proteínas Quinases Ativadas por Mitógeno / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Glioma / Mutação Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Genes Reporter / Proteínas Quinases Ativadas por Mitógeno / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Glioma / Mutação Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha