How to manage BRCA mutation carriers?
Horm Mol Biol Clin Investig
; 41(3)2020 May 27.
Article
em En
| MEDLINE
| ID: mdl-32459193
ABSTRACT
Inherited mutations in BRCA1 and BRCA2 genes increase the risk of development of cancer in organs especially in breast and ovary. Prevention and screening in BRCA mutation carriers are of high importance. Prophylactic surgeries are possible but are still insufficiently performed because they require surgical procedures in healthy patients. Guidelines for the management of BRCA mutations carriers must absolutely be part of the standard practice of all those involved in the management of these patients to increase the impact of the implementation of these preventive measures. There is no screening recommended for ovarian cancer. A risk-reducing bilateral salpingo-oophorectomy should be performed from age 35 to 40 years for BRCA1 mutation carriers and 40 to 45 years for BRCA2 mutation carriers. A screening for breast cancer should be performed annually from 30 years old by breast MRI and mammography. A risk-reducing bilateral mastectomy is recommended with nipple sparing mastectomy and immediate breast reconstruction from 30 years and before 40 years. A multidisciplinary care must be implemented for these patients with an important psychological support.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_muertes_prematuras_enfermedades_notrasmisibles
Assunto principal:
Quimioprevenção
/
Síndrome Hereditária de Câncer de Mama e Ovário
/
Mastectomia Profilática
/
Triagem de Portadores Genéticos
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
Idioma:
En
Revista:
Horm Mol Biol Clin Investig
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
França