Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice.

Kiyasu, Yoshiyuki; Kawada, Kenji; Hirai, Hideyo; Ogawa, Ryotaro; Hanada, Keita; Masui, Hideyuki; Nishikawa, Gen; Yamamoto, Takamasa; Mizuno, Rei; Itatani, Yoshiro; Kai, Masayuki; Taketo, Makoto Mark; Sakai, Yoshiharu

Kiyasu, Yoshiyuki; Kawada, Kenji; Hirai, Hideyo; Ogawa, Ryotaro; Hanada, Keita; Masui, Hideyuki; Nishikawa, Gen; Yamamoto, Takamasa; Mizuno, Rei; Itatani, Yoshiro; Kai, Masayuki; Taketo, Makoto Mark; Sakai, Yoshiharu.

Afiliação

Kiyasu Y; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Kawada K; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address: kkawada@kuhp.kyoto-u.ac.jp.
Hirai H; Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Ogawa R; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Hanada K; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Masui H; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Nishikawa G; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Yamamoto T; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Mizuno R; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Itatani Y; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Kai M; Oncology Research Laboratories, Oncology R&D Unit, R&D Division, Kyowa Kirin Co., Ltd., 3-6-6 Asahi-machi, Machida, Tokyo, 194-8533, Japan.
Taketo MM; Division of Experimental Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Sakai Y; Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.

Cancer Lett ; 487: 53-62, 2020 09 01.

Article em En | MEDLINE | ID: mdl-32473241

Assuntos

Terapia Baseada em Transplante de Células e Tecidos; Neoplasias Colorretais/genética; Neoplasias Hepáticas/genética; Proteínas Serina-Treonina Quinases/genética; Animais; Medula Óssea/metabolismo; Medula Óssea/patologia; Linhagem Celular Tumoral; Neoplasias Colorretais/patologia; Neoplasias Colorretais/terapia; Modelos Animais de Doenças; Progressão da Doença; Regulação Neoplásica da Expressão Gênica/genética; Xenoenxertos; Humanos; Neoplasias Hepáticas/patologia; Neoplasias Hepáticas/secundário; Neoplasias Hepáticas/terapia; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 9 da Matriz/genética; Camundongos; Células Mieloides/metabolismo; Células Mieloides/patologia; Metástase Neoplásica; Óxido Nítrico Sintase Tipo II/genética; Proteínas Serina-Treonina Quinases/uso terapêutico; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

CCR1; Colorectal cancer; Myeloid cell; Tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Serina-Treonina Quinases / Terapia Baseada em Transplante de Células e Tecidos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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