Annual decline in ß-cell function in patients with type 2 diabetes in China.
Diabetes Metab Res Rev
; 37(2): e3364, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-32515043
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the annual decline of ß-cell function correlated with disease duration in patients with type 2 diabetes in China.METHODS:
This cross-sectional study included 4792 adults with type 2 diabetes who were recruited from four university hospital diabetes clinics between April 2018 and November 2018. Baseline data were collected from electric medical records. Participants were divided into 21 groups with 1-year diabetes duration interval to assess the decline rate of ß-cell function. Homeostatic model assessment model (HOMA 2) model was applied to assess ß-cell function. Multiple linear regression model was used to evaluate the association between biochemical and clinical variables and ß-cell function.RESULTS:
In Chinese patients with type 2 diabetes, ß-cell function declined by 2% annually. Using angiotensin receptor blockade (ARB) (ß = .048; P = .011), metformin (ß = .138; P = .021), or insulin (ß = .142; P = .018) was associated with increased ß-cell function. However, increased BMI (ß = -.215; P = .022), alcohol consumption (ß = -.331; P < .001), haemoglobin A1c (ß = -.104; P = .027), or increased diabetes duration (ß = -.183; P = .003) was significantly and negatively associated with ß-cell function.CONCLUSIONS:
We determined that the annual rate of the ß-cell function decline was 2% in patients with type 2 diabetes in China. Moreover, we confirmed a positive relationship between ARB treatment and ß-cell function, while BMI and alcohol consumption were significantly and negatively associated with the ß-cell function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Problema de saúde:
1_doencas_nao_transmissiveis
/
2_muertes_prematuras_enfermedades_notrasmisibles
/
8_alcohol
Assunto principal:
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Diabetes Metab Res Rev
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China