Discovery of hydroxy pyrimidine Factor IXa inhibitors.
Bioorg Med Chem Lett
; 30(15): 127279, 2020 08 01.
Article
em En
| MEDLINE
| ID: mdl-32527459
ABSTRACT
The synthesis and structure activity relationship development of a pyrimidine series of heterocyclic Factor IXa inhibitors is described. Increased selectivity over Factor Xa inhibition was achieved through SAR expansion of the P1 element. Select compounds were evaluated in vivo to assess their plasma levels in rat.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Fator IXa
/
Descoberta de Drogas
/
Inibidores do Fator Xa
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article