Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b).

Hens, Bart; Bermejo, Marival; Cristofoletti, Rodrigo; Amidon, Gregory E; Amidon, Gordon L

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b).

Hens, Bart; Bermejo, Marival; Cristofoletti, Rodrigo; Amidon, Gregory E; Amidon, Gordon L.

Afiliação

Hens B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA.
Bermejo M; Department of Pharmaceutical and Pharmacological Sciences, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Cristofoletti R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA.
Amidon GE; Department Engineering Pharmacy Section, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain.
Amidon GL; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.

Pharmaceutics ; 12(6)2020 Jun 18.

Article em En | MEDLINE | ID: mdl-32570975

Palavras-chave

biopharmaceutics classification system (BCS), low aqueous solubility; biopredictive dissolution testing; in silico modeling; oral bioavailability; oral drug absorption; physiologically-based biopharmaceutics modeling (PBBM)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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