Emerging use of senolytics and senomorphics against aging and chronic diseases.
Med Res Rev
; 40(6): 2114-2131, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32578904
ABSTRACT
Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Senescência Celular
/
Diabetes Mellitus Tipo 2
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Med Res Rev
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China