Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim.

Basu, Sumit; Lien, Yi Ting Kayla; Vozmediano, Valvanera; Schlender, Jan-Frederik; Eissing, Thomas; Schmidt, Stephan; Niederalt, Christoph

Basu, Sumit; Lien, Yi Ting Kayla; Vozmediano, Valvanera; Schlender, Jan-Frederik; Eissing, Thomas; Schmidt, Stephan; Niederalt, Christoph.

Afiliação

Basu S; Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.
Lien YTK; Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.
Vozmediano V; Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.
Schlender JF; Clinical Pharmacometrics, Bayer AG, Leverkusen, Germany.
Eissing T; Clinical Pharmacometrics, Bayer AG, Leverkusen, Germany.
Schmidt S; Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.
Niederalt C; Clinical Pharmacometrics, Bayer AG, Leverkusen, Germany.

Front Pharmacol ; 11: 868, 2020.

Article em En | MEDLINE | ID: mdl-32595502

Palavras-chave

PK-Sim; children; monoclonal antibodies; pediatrics; physiologically based pharmacokinetic (PBPK) modeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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