Preparation of Functionalized α,ß-Unsaturated Sulfonamides via Olefin Cross-Metathesis.
Org Lett
; 22(13): 4970-4973, 2020 07 02.
Article
em En
| MEDLINE
| ID: mdl-32610933
ABSTRACT
The synthesis of functionalized α,ß-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda-Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Polônia