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An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway.
Chen, Jingyao; Zhao, Lei; Peng, Hongling; Dai, Siqi; Quan, Yuan; Wang, Manli; Wang, Jian; Bi, Zhanying; Zheng, Ying; Zhou, Shengtao; Liu, Yu; Chen, Chong; Na, Feifei.
Afiliação
  • Chen J; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Zhao L; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Peng H; West China Second Hospital, Sichuan University, Chengdu, China.
  • Dai S; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Quan Y; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Wang M; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Wang J; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Bi Z; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Zheng Y; West China Second Hospital, Sichuan University, Chengdu, China.
  • Zhou S; West China Second Hospital, Sichuan University, Chengdu, China.
  • Liu Y; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Chen C; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. chongchen@scu.edu.cn.
  • Na F; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. nafeifei@foxmail.com.
Cancer Gene Ther ; 28(1-2): 112-125, 2021 02.
Article em En | MEDLINE | ID: mdl-32632269
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Proteínas Proto-Oncogênicas / Neoplasias do Endométrio / Avaliação Pré-Clínica de Medicamentos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Gene Ther Assunto da revista: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Proteínas Proto-Oncogênicas / Neoplasias do Endométrio / Avaliação Pré-Clínica de Medicamentos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Gene Ther Assunto da revista: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China