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Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Franco, Caio H; Warhurst, David C; Bhattacharyya, Tapan; Au, Ho Y A; Le, Hai; Giardini, Miriam A; Pascoalino, Bruno S; Torrecilhas, Ana Claudia; Romera, Lavinia M D; Madeira, Rafael Pedro; Schenkman, Sergio; Freitas-Junior, Lucio H; Chatelain, Eric; Miles, Michael A; Moraes, Carolina B.
Afiliação
  • Franco CH; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Warhurst DC; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  • Bhattacharyya T; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  • Au HYA; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  • Le H; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  • Giardini MA; Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
  • Pascoalino BS; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, Brazil.
  • Torrecilhas AC; Department of Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil.
  • Romera LMD; Department of Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil.
  • Madeira RP; Department of Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil.
  • Schenkman S; Department of Microbiology, Immunology and Parasitology, UNIFESP, São Paulo, SP, Brazil.
  • Freitas-Junior LH; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil; Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
  • Chatelain E; Drugs for Neglected Diseases Initiative, Geneva, Switzerland.
  • Miles MA; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
  • Moraes CB; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil; Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, R
Int J Parasitol Drugs Drug Resist ; 13: 107-120, 2020 08.
Article em En | MEDLINE | ID: mdl-32688218
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 Problema de saúde: 2_enfermedades_transmissibles Assunto principal: Trypanosoma cruzi / Resistência a Múltiplos Medicamentos / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 Problema de saúde: 2_enfermedades_transmissibles Assunto principal: Trypanosoma cruzi / Resistência a Múltiplos Medicamentos / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil