Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice.

Xu, Yong; Zhang, Yating; Zhang, Jian-Hua; Han, Kang; Zhang, Xinwei; Bai, Xue; You, Lin-Hao; Yu, Peng; Shi, Zhenhua; Chang, Yan-Zhong; Gao, Guofen

Xu, Yong; Zhang, Yating; Zhang, Jian-Hua; Han, Kang; Zhang, Xinwei; Bai, Xue; You, Lin-Hao; Yu, Peng; Shi, Zhenhua; Chang, Yan-Zhong; Gao, Guofen.

Afiliação

Xu Y; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Zhang Y; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Zhang JH; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Han K; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Zhang X; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Bai X; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
You LH; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Yu P; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Shi Z; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China.
Chang YZ; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China. Electronic address: chang7676@163.com.
Gao G; Laboratory of Molecular Iron Metabolism, College of Life Sciences, Hebei Normal University, No. 20, Nan Er Huan East Road, Shijiazhuang, 050024, China. Electronic address: guofen83@hotmail.com.

Free Radic Biol Med ; 158: 84-95, 2020 10.

Article em En | MEDLINE | ID: mdl-32707154

Assuntos

Doença de Alzheimer; Astrócitos; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Astrócitos/metabolismo; Encéfalo/metabolismo; Modelos Animais de Doenças; Hepcidinas/genética; Ferro; Camundongos; Camundongos Transgênicos; Estresse Oxidativo; Presenilina-1/genética; Presenilina-1/metabolismo

Palavras-chave

Alzheimer's disease; Aß; Hepcidin; Iron deposition; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_alzheimer_other_dementias / 6_mental_health_behavioral_disorders Assunto principal: Astrócitos / Doença de Alzheimer Limite: Animals Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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