Innate responses to gut microbiota; critical assessment of the necessary experimental controls.
Curr Opin Microbiol
; 59: 34-41, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-32846371
ABSTRACT
The intestinal microbiota is comprises a diverse community of micro-organisms that interact with many host processes. Innate immune responses to the gut microbiota are of particular importance as they influence many other downstream responses. This fascinating host-microbe crosstalk is a rapidly expanding field of study; thus, it is critical to ensure reproducibility between studies and applicability to human clinical trials through standardization of experiments. We discuss here recent advances in the field including the spectrum of colonization statuses available, the critical importance of colonization timing, the dynamics of the microbial community, and the required housing of animals, as they pertain to appropriate experimental control and design.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_zoonosis
Assunto principal:
Projetos de Pesquisa
/
Microbioma Gastrointestinal
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article