Isobutanol production freed from biological limits using synthetic biochemistry.

Sherkhanov, Saken; Korman, Tyler P; Chan, Sum; Faham, Salem; Liu, Hongjiang; Sawaya, Michael R; Hsu, Wan-Ting; Vikram, Ellee; Cheng, Tiffany; Bowie, James U

Sherkhanov, Saken; Korman, Tyler P; Chan, Sum; Faham, Salem; Liu, Hongjiang; Sawaya, Michael R; Hsu, Wan-Ting; Vikram, Ellee; Cheng, Tiffany; Bowie, James U.

Afiliação

Sherkhanov S; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Chan S; Invizyne Technologies, Inc., Monrovia, CA, USA.
Faham S; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Liu H; Vertex Pharmaceuticals, Boston, MA, USA.
Sawaya MR; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Hsu WT; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Vikram E; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Cheng T; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.
Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.

Nat Commun ; 11(1): 4292, 2020 08 27.

Article em En | MEDLINE | ID: mdl-32855421

Assuntos

Bioquímica/métodos; Butanóis/metabolismo; Enzimas/metabolismo; Acetolactato Sintase/química; Acetolactato Sintase/metabolismo; Trifosfato de Adenosina; Oxirredutases do Álcool/genética; Oxirredutases do Álcool/metabolismo; Bioquímica/instrumentação; Reatores Biológicos; Sistema Livre de Células; Evolução Molecular Direcionada; Enzimas/química; Enzimas/genética; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Glucose/metabolismo; Temperatura; Termodinâmica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bioquímica / Butanóis / Enzimas Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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