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Accelerated cortical thinning and volume reduction over time in young people at high genetic risk for bipolar disorder.
Roberts, G; Lenroot, R; Overs, B; Fullerton, J; Leung, V; Ridgway, K; Stuart, A; Frankland, A; Levy, F; Hadzi-Pavlovic, D; Breakspear, M; Mitchell, P B.
Afiliação
  • Roberts G; School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
  • Lenroot R; Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
  • Overs B; School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
  • Fullerton J; Neuroscience Research Australia, Sydney, NSW, Australia.
  • Leung V; School of Medicine, University of New Mexico, Albuquerque, New Mexico.
  • Ridgway K; Neuroscience Research Australia, Sydney, NSW, Australia.
  • Stuart A; Neuroscience Research Australia, Sydney, NSW, Australia.
  • Frankland A; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Levy F; School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
  • Hadzi-Pavlovic D; Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
  • Breakspear M; School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
  • Mitchell PB; Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
Psychol Med ; 52(7): 1344-1355, 2022 05.
Article em En | MEDLINE | ID: mdl-32892764
ABSTRACT

BACKGROUND:

Bipolar disorder (BD) is a familial psychiatric disorder associated with frontotemporal and subcortical brain abnormalities. It is unclear whether such abnormalities are present in relatives without BD, and little is known about structural brain trajectories in those at risk.

METHOD:

Neuroimaging was conducted at baseline and at 2-year follow-up interval in 90 high-risk individuals with a first-degree BD relative (HR), and 56 participants with no family history of mental illness who could have non-BD diagnoses. All 146 subjects were aged 12-30 years at baseline. We examined longitudinal change in gray and white matter volume, cortical thickness, and surface area in the frontotemporal cortex and subcortical regions.

RESULTS:

Compared to controls, HR participants showed accelerated cortical thinning and volume reduction in right lateralised frontal regions, including the inferior frontal gyrus, lateral orbitofrontal cortex, frontal pole and rostral middle frontal gyrus. Independent of time, the HR group had greater cortical thickness in the left caudal anterior cingulate cortex, larger volume in the right medial orbitofrontal cortex and greater area of right accumbens, compared to controls. This pattern was evident even in those without the new onset of psychopathology during the inter-scan interval.

CONCLUSIONS:

This study suggests that differences previously observed in BD are developing prior to the onset of the disorder. The pattern of pathological acceleration of cortical thinning is likely consistent with a disturbance of molecular mechanisms responsible for normal cortical thinning. We also demonstrate that neuroanatomical differences in HR individuals may be progressive in some regions and stable in others.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Transtorno Bipolar Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Revista: Psychol Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Transtorno Bipolar Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Revista: Psychol Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália
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