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Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Penkava, Frank; Velasco-Herrera, Martin Del Castillo; Young, Matthew D; Yager, Nicole; Nwosu, Lilian N; Pratt, Arthur G; Lara, Alicia Lledo; Guzzo, Charlotte; Maroof, Ash; Mamanova, Lira; Cole, Suzanne; Efremova, Mirjana; Simone, Davide; Filer, Andrew; Brown, Chrysothemis C; Croxford, Andrew L; Isaacs, John D; Teichmann, Sarah; Bowness, Paul; Behjati, Sam; Hussein Al-Mossawi, M.
Afiliação
  • Penkava F; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
  • Velasco-Herrera MDC; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Young MD; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Yager N; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
  • Nwosu LN; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
  • Pratt AG; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
  • Lara AL; Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
  • Guzzo C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
  • Maroof A; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Mamanova L; UCB Pharma, 216 Bath road, Slough, SL1 3WE, UK.
  • Cole S; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Efremova M; UCB Pharma, 216 Bath road, Slough, SL1 3WE, UK.
  • Simone D; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Filer A; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
  • Brown CC; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing, Birmingham, UK.
  • Croxford AL; Infection, Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
  • Isaacs JD; Idorsia Pharmaceuticals Ltd., Drug Discovery Immunology, Hegenheimermattweg 91, 4123, Allschwill, Switzerland.
  • Teichmann S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
  • Bowness P; Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
  • Behjati S; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.
  • Hussein Al-Mossawi M; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
Nat Commun ; 11(1): 4767, 2020 09 21.
Article em En | MEDLINE | ID: mdl-32958743
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido Sinovial / Artrite Psoriásica / Receptores de Retorno de Linfócitos / Linfócitos T CD8-Positivos / Seleção Clonal Mediada por Antígeno Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido Sinovial / Artrite Psoriásica / Receptores de Retorno de Linfócitos / Linfócitos T CD8-Positivos / Seleção Clonal Mediada por Antígeno Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido