Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies.
Neurodegener Dis Manag
; 10(6): 357-367, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32967534
ABSTRACT
Background:
Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials &methods:
12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted.Results:
In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline.Conclusion:
Functional decline does not depend on HSv in mild AD and DLB.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
Problema de saúde:
1_doencas_nao_transmissiveis
Assunto principal:
Atividades Cotidianas
/
Doença por Corpos de Lewy
/
Doença de Alzheimer
/
Hipocampo
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Neurodegener Dis Manag
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Noruega