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Genome-wide association study identifies 48 common genetic variants associated with handedness.
Cuellar-Partida, Gabriel; Tung, Joyce Y; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A; Barroso, Inês; Beckmann, Jacques S; Boks, Marco P; Boomsma, Dorret I; Boyd, Heather A; Breteler, Monique M B; Campbell, Harry; Chasman, Daniel I; Cherkas, Lynn F; Davies, Gail; de Geus, Eco J C; Deary, Ian J; Deloukas, Panos; Dick, Danielle M; Duffy, David L; Eriksson, Johan G; Esko, Tõnu; Feenstra, Bjarke; Geller, Frank; Gieger, Christian; Giegling, Ina; Gordon, Scott D; Han, Jiali; Hansen, Thomas F; Hartmann, Annette M; Hayward, Caroline; Heikkilä, Kauko; Hicks, Andrew A; Hirschhorn, Joel N; Hottenga, Jouke-Jan; Huffman, Jennifer E; Hwang, Liang-Dar; Ikram, M Arfan; Kaprio, Jaakko; Kemp, John P; Khaw, Kay-Tee; Klopp, Norman; Konte, Bettina; Kutalik, Zoltan; Lahti, Jari; Li, Xin; Loos, Ruth J F; Luciano, Michelle; Magnusson, Sigurdur H.
Afiliação
  • Cuellar-Partida G; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Tung JY; 23andMe, Inc., Sunnyvale, CA, USA.
  • Eriksson N; 23andMe, Inc., Sunnyvale, CA, USA.
  • Albrecht E; 23andMe, Inc., Sunnyvale, CA, USA.
  • Aliev F; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Andreassen OA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
  • Barroso I; Karabuk University, Faculty of Business, Karabük, Turkey.
  • Beckmann JS; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Boks MP; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Boomsma DI; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
  • Boyd HA; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Breteler MMB; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Campbell H; Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
  • Chasman DI; Department of Psychiatry, UMC Utrecht Brain Center, University Utrecht, Utrecht, The Netherlands.
  • Cherkas LF; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Davies G; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • de Geus EJC; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Deary IJ; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Deloukas P; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Dick DM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Duffy DL; Harvard Medical School, Boston, MA, USA.
  • Eriksson JG; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Esko T; Department of Psychology, University of Edinburgh, Edinburgh, UK.
  • Feenstra B; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Geller F; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Gieger C; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Giegling I; Department of Psychology, University of Edinburgh, Edinburgh, UK.
  • Gordon SD; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Han J; William Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health, Queen Mary University of London, London, UK.
  • Hansen TF; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
  • Hartmann AM; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Hayward C; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Heikkilä K; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Hicks AA; Folkhälsan Research Center, Helsinki, Finland.
  • Hirschhorn JN; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore, Singapore.
  • Hottenga JJ; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Huffman JE; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Hwang LD; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ikram MA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Kaprio J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Kemp JP; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Khaw KT; German Center for Diabetes Research (DZD), München-Neuherberg, Neuherberg, Germany.
  • Klopp N; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
  • Konte B; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Kutalik Z; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
  • Lahti J; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
  • Li X; Institute of Biological Psychiatry, Mental Health Services of Copenhagen, Copenhagen, Denmark.
  • Loos RJF; Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark.
  • Luciano M; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
  • Magnusson SH; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Nat Hum Behav ; 5(1): 59-70, 2021 01.
Article em En | MEDLINE | ID: mdl-32989287
ABSTRACT
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Lateralidade Funcional Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Lateralidade Funcional Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália