Galectin-3 plasma levels in adult congenital heart disease and the pressure overloaded right ventricle: reason matters.
Biomark Med
; 14(13): 1197-1205, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-33021383
ABSTRACT
Aim:
To assess galectin-3 (Gal-3) levels and their relationship with clinical status and right ventricular (RV) performance in adults with RV pressure overload of various mechanisms due to congenital heart disease. Materials &methods:
A cross-sectional study was conducted. Patients underwent clinical examination, blood testing and transthoracic echocardiography.Results:
The study included 63 patients with congenitally corrected transposition of the great arteries, 41 patients with Eisenmenger syndrome and 20 healthy controls. Gal-3 concentrations were higher in patients compared with controls (7.83 vs 6.11 ng/ml; p = 0.002). Biomarker levels correlated with age, New York Health Association class, N-terminal probrain natriuretic peptide and RV function only in congenitally corrected transposition of the great arteries patients.Conclusion:
Gal-3 profile in congenital heart disease patients and pressure-overloaded RV differs according to the cause of pressure overload.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Galectina 3
/
Cardiopatias Congênitas
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomark Med
Assunto da revista:
BIOQUIMICA
/
MEDICINA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Polônia