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Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Isbilir, Ali; Möller, Jan; Arimont, Marta; Bobkov, Vladimir; Perpiñá-Viciano, Cristina; Hoffmann, Carsten; Inoue, Asuka; Heukers, Raimond; de Graaf, Chris; Smit, Martine J; Annibale, Paolo; Lohse, Martin J.
Afiliação
  • Isbilir A; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
  • Möller J; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Arimont M; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
  • Bobkov V; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Perpiñá-Viciano C; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
  • Hoffmann C; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
  • Inoue A; argenx BVBA, Zwijnaarde 9052, Belgium.
  • Heukers R; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • de Graaf C; Institute of Molecular Cell Biology, University Hospital Jena, University of Jena, 07745 Jena, Germany.
  • Smit MJ; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Annibale P; Institute of Molecular Cell Biology, University Hospital Jena, University of Jena, 07745 Jena, Germany.
  • Lohse MJ; Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578 Sendai, Japan.
Proc Natl Acad Sci U S A ; 117(46): 29144-29154, 2020 11 17.
Article em En | MEDLINE | ID: mdl-33148803
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dimerização / Receptores CXCR4 / Microscopia de Fluorescência Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dimerização / Receptores CXCR4 / Microscopia de Fluorescência Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha