Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?-Clues from exotic animal reservoirs.
Pathog Dis
; 79(1)2021 01 09.
Article
em En
| MEDLINE
| ID: mdl-33289808
ABSTRACT
A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against COVID-19 infection in humans. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
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2_ODS3
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4_TD
Problema de saúde:
1_doencas_nao_transmissiveis
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1_doencas_transmissiveis
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2_enfermedades_transmissibles
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4_pneumonia
Assunto principal:
Zoonoses
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Receptores KIR
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Receptores Semelhantes a Lectina de Células NK
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Proteína 3 que Contém Domínio de Pirina da Família NLR
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Síndrome da Liberação de Citocina
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COVID-19
Idioma:
En
Revista:
Pathog Dis
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia