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Comparative Morphological Characteristics of the Results of Implantation of Decellularized and Recellularized Porcine Skin Scaffolds.
Sotnichenko, A S; Gilevich, I V; Melkonyan, K I; Yutskevich, Y A; Rusinova, T V; Karakulev, A V; Bogdanov, S B; Aladina, V A; Belich, Yu A; Gumenyuk, S E; Ushmarov, D I; Bykov, I M; Redko, A N; Porhanov, V A; Alekseenko, S N.
Afiliação
  • Sotnichenko AS; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia. alex24.88@mail.ru.
  • Gilevich IV; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Melkonyan KI; Research Institute - S. V. Ochapovsky Krasnodar Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Krai, Krasnodar, Russia.
  • Yutskevich YA; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Rusinova TV; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Karakulev AV; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Bogdanov SB; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Aladina VA; Research Institute - S. V. Ochapovsky Krasnodar Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Krai, Krasnodar, Russia.
  • Belich YA; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Gumenyuk SE; Research Institute - S. V. Ochapovsky Krasnodar Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Krai, Krasnodar, Russia.
  • Ushmarov DI; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Bykov IM; Research Institute - S. V. Ochapovsky Krasnodar Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Krai, Krasnodar, Russia.
  • Redko AN; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Porhanov VA; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
  • Alekseenko SN; Kuban State Medical University, Ministry of Health od the Russian Federation, Krasnodar, Russia.
Bull Exp Biol Med ; 170(3): 378-383, 2021 Jan.
Article em En | MEDLINE | ID: mdl-33452991
ABSTRACT
The tissue reaction of pig skin to implantation of decellularized and recellularized dermal matrices on a formed wound defect was evaluated by histological methods on days 2, 5, 8, 16, and 20 after surgery. Differences in tissue response to different matrices were identified. In experimental wounds coated with decellularized dermal matrices, we observed the formation of a scar tissue, which required autodermoplasty on day 12 of the experiment. In wounds coated with recellularized dermal matrices, all layers of the skin completely recovered by day 20 after surgery with the formation of full dermal and epidermal layers. Our findings suggest that reparative morphological changes in the wound depend on the presence of fibroblasts in the implanted dermal matrix.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Engenharia Tecidual / Alicerces Teciduais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Engenharia Tecidual / Alicerces Teciduais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa