Comparison of Antiviral Activity of Gemcitabine with 2'-Fluoro-2'-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2.

Jang, Yejin; Shin, Jin Soo; Lee, Myoung Kyu; Jung, Eunhye; An, Timothy; Kim, Uk-Il; Kim, Kyungjin; Kim, Meehyein

Jang, Yejin; Shin, Jin Soo; Lee, Myoung Kyu; Jung, Eunhye; An, Timothy; Kim, Uk-Il; Kim, Kyungjin; Kim, Meehyein.

Afiliação

Jang Y; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Shin JS; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Lee MK; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Jung E; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
An T; Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Kim UI; Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Korea.
Kim K; Research and Development Center, ST Pharm Co., Ltd., Seoul 01694, Korea.
Kim M; Research and Development Center, ST Pharm Co., Ltd., Seoul 01694, Korea.

Int J Mol Sci ; 22(4)2021 Feb 04.

Article em En | MEDLINE | ID: mdl-33557278

Assuntos

Monofosfato de Adenosina/análogos & derivados; Alanina/análogos & derivados; Tratamento Farmacológico da COVID-19; Desoxicitidina/análogos & derivados; SARS-CoV-2/efeitos dos fármacos; Monofosfato de Adenosina/farmacologia; Alanina/farmacologia; Animais; Antivirais/farmacologia; COVID-19/metabolismo; COVID-19/virologia; Linhagem Celular; Chlorocebus aethiops; Desoxicitidina/farmacologia; Quimioterapia Combinada; Humanos; Concentração Inibidora 50; SARS-CoV-2/fisiologia; Células Vero; Replicação Viral/efeitos dos fármacos; Gencitabina

Palavras-chave

2'-fluoro-2'-deoxycytidine; SARS-CoV-2; antiviral activity; gemcitabine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monofosfato de Adenosina / Desoxicitidina / Alanina / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

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