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PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3ß-Mediated c-Myc and Pim-1 Proteasomal Degradation.
Scarpa, Mario; Singh, Prerna; Bailey, Christopher M; Lee, Jonelle K; Kapoor, Shivani; Lapidus, Rena G; Niyongere, Sandrine; Sangodkar, Jaya; Wang, Yin; Perrotti, Danilo; Narla, Goutham; Baer, Maria R.
Afiliação
  • Scarpa M; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Singh P; Department of Medicine.
  • Bailey CM; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Lee JK; Department of Surgery and.
  • Kapoor S; Division of Immunotherapy, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
  • Lapidus RG; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Niyongere S; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Sangodkar J; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Wang Y; Department of Medicine.
  • Perrotti D; The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
  • Narla G; Department of Medicine.
  • Baer MR; Division of Genetic Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan.
Mol Cancer Ther ; 20(4): 676-690, 2021 04.
Article em En | MEDLINE | ID: mdl-33568357
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genes myc / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Proteínas Proto-Oncogênicas c-pim-1 / Proteína Fosfatase 2 / Glicogênio Sintase Quinase 3 beta Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genes myc / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Proteínas Proto-Oncogênicas c-pim-1 / Proteína Fosfatase 2 / Glicogênio Sintase Quinase 3 beta Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2021 Tipo de documento: Article