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Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.
Skwarski, Michael; McGowan, Daniel R; Belcher, Elizabeth; Di Chiara, Francesco; Stavroulias, Dionisios; McCole, Mark; Derham, Jennifer L; Chu, Kwun-Ye; Teoh, Eugene; Chauhan, Jagat; O'Reilly, Dawn; Harris, Benjamin H L; Macklin, Philip S; Bull, Joshua A; Green, Marcus; Rodriguez-Berriguete, Gonzalo; Prevo, Remko; Folkes, Lisa K; Campo, Leticia; Ferencz, Petra; Croal, Paula L; Flight, Helen; Qi, Cathy; Holmes, Jane; O'Connor, James P B; Gleeson, Fergus V; McKenna, W Gillies; Harris, Adrian L; Bulte, Daniel; Buffa, Francesca M; Macpherson, Ruth E; Higgins, Geoff S.
Afiliação
  • Skwarski M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • McGowan DR; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Belcher E; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Di Chiara F; Radiation Physics and Protection, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Stavroulias D; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • McCole M; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Derham JL; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Chu KY; Department of Cellular Pathology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Teoh E; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Chauhan J; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • O'Reilly D; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Harris BHL; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Macklin PS; Ludwig Institute for Cancer Research Oxford, University of Oxford, Oxford, England, United Kingdom.
  • Bull JA; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Green M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Rodriguez-Berriguete G; Nuffield Department of Medicine, University of Oxford, Oxford, England, United Kingdom.
  • Prevo R; Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, England, United Kingdom.
  • Folkes LK; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Campo L; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Ferencz P; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Croal PL; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Flight H; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Qi C; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom.
  • Holmes J; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom.
  • O'Connor JPB; Oncology Clinical Trials Office, Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Gleeson FV; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom.
  • McKenna WG; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom.
  • Harris AL; Division of Cancer Sciences, University of Manchester, Manchester, England, United Kingdom.
  • Bulte D; Department of Radiology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
  • Buffa FM; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Macpherson RE; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.
  • Higgins GS; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom.
Clin Cancer Res ; 27(9): 2459-2469, 2021 05 01.
Article em En | MEDLINE | ID: mdl-33597271
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / Regulação Neoplásica da Expressão Gênica / Atovaquona / Hipóxia Tumoral / Mitocôndrias Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / Regulação Neoplásica da Expressão Gênica / Atovaquona / Hipóxia Tumoral / Mitocôndrias Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido