Novel mutations in FSIP2 lead to multiple morphological abnormalities of the sperm flagella and poor ICSI prognosis.

Liu, Mohan; Sun, Yongkang; Li, Yaqian; Sun, Jianfeng; Yang, Yihong; Shen, Ying

Liu, Mohan; Sun, Yongkang; Li, Yaqian; Sun, Jianfeng; Yang, Yihong; Shen, Ying.

Afiliação

Liu M; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China; State Key Laborator
Sun Y; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Li Y; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Sun J; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Yang Y; Reproduction Medical Center of West China Second University Hospital, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu 610041, China. Electronic address: yyhpumc@foxmail.com.
Shen Y; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Gene ; 781: 145536, 2021 May 20.

Article em En | MEDLINE | ID: mdl-33631238

Assuntos

Dineínas do Axonema/genética; Infertilidade Masculina/genética; Mutação com Perda de Função; Proteínas de Plasma Seminal/genética; Cauda do Espermatozoide/patologia; Adulto; Animais; Feminino; Humanos; Infertilidade Masculina/patologia; Masculino; Camundongos; Gravidez; Injeções de Esperma Intracitoplásmicas; Testículo/metabolismo; Sequenciamento do Exoma

Palavras-chave

FSIP2; ICSI; Loss-of-function mutations; MMAF; Male infertility; WES

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cauda do Espermatozoide / Proteínas de Plasma Seminal / Dineínas do Axonema / Mutação com Perda de Função / Infertilidade Masculina Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Gene Ano de publicação: 2021 Tipo de documento: Article

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