Synthesis, characterization, biological evaluation and molecular docking of a new quinazolinone-based derivative as a potent dual inhibitor for VEGFR-2 and EGFR tyrosine kinases.

Riadi, Yassine; Alamri, Mubarak A; Geesi, Mohammed H; Anouar, El Hassane; Ouerghi, Oussama; Alabbas, Alhumaidi B; Alossaimi, Manal A; Altharawi, Ali; Dehbi, Oussama; Alqahtani, Safar M

Riadi, Yassine; Alamri, Mubarak A; Geesi, Mohammed H; Anouar, El Hassane; Ouerghi, Oussama; Alabbas, Alhumaidi B; Alossaimi, Manal A; Altharawi, Ali; Dehbi, Oussama; Alqahtani, Safar M.

Afiliação

Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Alamri MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Geesi MH; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Anouar EH; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Ouerghi O; Department of Physic, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Alabbas AB; Université Tunis El Manar, Tunis, Tunisia.
Alossaimi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Altharawi A; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Dehbi O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Alqahtani SM; Department of Chemistry, College of Science and Arts of Al Qurayyat, Jouf University, Saudi Arabia.

J Biomol Struct Dyn ; 40(15): 6810-6816, 2022 09.

Article em En | MEDLINE | ID: mdl-33682611

Assuntos

Antineoplásicos; Receptor 2 de Fatores de Crescimento do Endotélio Vascular; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Receptores ErbB/metabolismo; Humanos; Simulação de Acoplamento Molecular; Estrutura Molecular; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Quinazolinonas/farmacologia; Relação Estrutura-Atividade; Tirosina; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/farmacologia

Palavras-chave

MD simulation; Quinazolinone; S-arylation; docking; tyrosine kinase

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google