Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem.
Nanomedicine
; 34: 102370, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33713859
ABSTRACT
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with poor prognosis. Therapeutic drugs for RCC can easily develop resistance or have unignorable toxicity or limited efficiency. Here, the thermosensitive mitochondrial metabolism-interfering anticancer drug lonidamine (LND) was combined with the photothermal material polydopamine (PDA) to treat RCC. To delivery drugs accurately to RCC site, LND and PDA were loaded in stellate mesoporous silica nanoparticles (MSNs) with a large surface area and cloaked with RCC membranes (MLP@M). The results showed that MLP@M exhibited excellent tumor targeting ability. The synergistic effects of LND and PDA in MLP@M were greatly enhanced when triggered by an 808â¯nm laser. Moreover, the antiproliferative and tumor suppressing abilities were enhanced with good biocompatibility after MLP@Mâ¯+â¯laser treatment. Additionally, 80% of RCC tumor-bearing mice treated with MLP@Mâ¯+â¯laser did not relapse. Our study provides a potential therapeutic approach for RCC treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Carcinoma de Células Renais
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas
/
Terapia Fototérmica
/
Indazóis
/
Indóis
/
Neoplasias Renais
/
Mitocôndrias
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nanomedicine
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China