Stability Issues, Probable Approaches for Stabilization and Associated Patents in the Pharmaceutical Field for Oleosome, A Novel Carrier for Drug Delivery.
Recent Pat Nanotechnol
; 16(3): 207-218, 2022.
Article
em En
| MEDLINE
| ID: mdl-33726660
ABSTRACT
Oleosomes are oil-containing micro-carriers of natural origin that are comprised of special oleosin proteins embedded with a monolayer of phospholipids having a triacylglycerol core. Due to their unique structure and non-toxicity in the biological system, these oil carriers are becoming very eye-catching for formulation development in the field of pharmacy. Consequently, oleosome offers emoliency, occlusivity, self-emulsification, anti-oxidant, and film-forming properties, which leads to controlled and sustained release of encapsulated bio-actives. It is also feasible to load oil-soluble ingredients, such as fragrance, vitamins (retinol), and lipophilic drug moieties inside the core. Being a natural carrier, it shows some stability issues (leakage of oil from the core, oxidation of the loaded oil, aggregation of oil droplets), which are controllable. In this review, we have focused on the various stability issues, the techniques (coating, surface modification, solvents) and how to overcome those problems, and how to load any lipophilic drug into the oil core, and we have also linked patent research works in the field of formulation development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmácia
/
Gotículas Lipídicas
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Recent Pat Nanotechnol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Índia