Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure.
Blood Cancer J
; 11(3): 65, 2021 03 26.
Article
em En
| MEDLINE
| ID: mdl-33771971
ABSTRACT
Magnesium is an essential element that is involved in critical metabolic pathways. A diet deficient in magnesium is associated with an increased risk of developing cancer. Few studies have reported whether a serum magnesium level below the reference range (RR) is associated with prognosis in patients with diffuse large B cell lymphoma (DLBCL). Using a retrospective approach in DLBCL patients undergoing autologous stem cell transplant (AHSCT), we evaluated the association of hypomagnesemia with survival. Totally, 581 patients eligible for AHSCT with a serum magnesium level during the immediate pre-transplant period were identified and 14.1% (82/581) had hypomagnesemia. Hypomagnesemia was associated with an inferior event-free (EFS) and overall survival (OS) compared to patients with a serum magnesium level within RR; median EFS 3.9 years (95% CI 1.63-8.98 years) versus 6.29 years (95% CI 4.73-8.95 years) with HR 1.63 (95% CI 1.09-2.43, p = 0.017) for EFS, and median OS 7.3 years (95% CI 2.91-upper limit not estimable) versus 9.7 years (95% CI 6.92-12.3 years) with HR 1.90 (95% CI 1.22-2.96, p = 0.005) for OS months 0-12, respectively. These findings suggest a potentially actionable prognostic factor for patients with DLBCL undergoing AHSCT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma Difuso de Grandes Células B
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Transplante de Células-Tronco Hematopoéticas
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Magnésio
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Deficiência de Magnésio
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Blood Cancer J
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos