Efficacy and safety of methylprednisolone against acute respiratory distress syndrome: A systematic review and meta-analysis.
Medicine (Baltimore)
; 100(14): e25408, 2021 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-33832136
ABSTRACT
BACKGROUND:
Acute respiratory distress syndrome (ARDS) is caused by an inflammatory injury to the lung. Dysregulated inflammation is the cardinal feature of ARDS. Methylprednisolone is an option for treating ARDS. However, the benefits and adverse effects of methylprednisolone have not been well assessed in patients with ARDS. This study aimed to evaluate the efficacy and safety of methylprednisolone against ARDS. MATERIAL ANDMETHODS:
The electronic database of Embase, PubMed, the Cochrane Library, CNKI, and Wanfang were searched, and randomized controlled trials (RCTs) reporting the efficacy and safety of methylprednisolone for ARDS were included. Revman 5.3 and Stata 15.0 were used to conduct the analysis. The fixed-effects model was used to calculate summary odds ratios (ORs) and 95% confidence interval (CIs).RESULTS:
Ten RCTs studies involving 692 patients with ARDS. The summary results demonstrated that, compared with placebo, methylprednisolone had a statistically significant effect on mortality (ORâ=â0.64; 95% CI 0.43-0.95, I2â=â42%); the time of mechanical ventilation (MD)â=â-2.70, 95% CI -3.31 to -2.10; I2â=â0%) in patients with ARDS, but it was not associated with increased rates of adverse events (ORâ=â0.80; 95% CI 0.34-1.86; I2â=â58%).CONCLUSIONS:
This systematic review and meta-analysis demonstrated that Methylprednisolone is safe against ARDS. It may reduce mortality and shorten the time of mechanical ventilation. However, well-designed and large-sample studies were required to fully characterize the efficacy and safety of methylprednisolone against ARDS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_other_respiratory_diseases
Assunto principal:
Respiração Artificial
/
Síndrome do Desconforto Respiratório
/
Metilprednisolona
/
Anti-Inflamatórios
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China