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VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics.
Davegårdh, Cajsa; Säll, Johanna; Benrick, Anna; Broholm, Christa; Volkov, Petr; Perfilyev, Alexander; Henriksen, Tora Ida; Wu, Yanling; Hjort, Line; Brøns, Charlotte; Hansson, Ola; Pedersen, Maria; Würthner, Jens U; Pfeffer, Klaus; Nilsson, Emma; Vaag, Allan; Stener-Victorin, Elisabet; Pircs, Karolina; Scheele, Camilla; Ling, Charlotte.
Afiliação
  • Davegårdh C; Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden.
  • Säll J; Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden.
  • Benrick A; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Broholm C; School of Health Sciences, University of Skövde, Skövde, Sweden.
  • Volkov P; Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
  • Perfilyev A; Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden.
  • Henriksen TI; Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden.
  • Wu Y; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Hjort L; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Brøns C; Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
  • Hansson O; Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark.
  • Pedersen M; Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
  • Würthner JU; Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Pfeffer K; Finnish Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland.
  • Nilsson E; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Vaag A; ADC Therapeutics, Biopole, Epalinges, Switzerland.
  • Stener-Victorin E; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Pircs K; Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden.
  • Scheele C; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Ling C; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Nat Commun ; 12(1): 2431, 2021 04 23.
Article em En | MEDLINE | ID: mdl-33893273
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Células-Tronco / Diferenciação Celular / Mioblastos / Proteínas de Transporte Vesicular / Diabetes Mellitus Tipo 2 / Epigenômica / Proteínas Relacionadas à Autofagia Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Células-Tronco / Diferenciação Celular / Mioblastos / Proteínas de Transporte Vesicular / Diabetes Mellitus Tipo 2 / Epigenômica / Proteínas Relacionadas à Autofagia Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia