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Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Okaniwa, Masanori; Shibata, Akira; Ochida, Atsuko; Akao, Yuichiro; White, Karen L; Shackleford, David M; Duffy, Sandra; Lucantoni, Leonardo; Dey, Sumanta; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Aguiar, Anna Caroline C; Sturm, Angelika; Crespo, Benigno; Sanz, Laura M; Churchyard, Alisje; Baum, Jake; Pereira, Dhelio B; Guido, Rafael V C; Dechering, Koen J; Wittlin, Sergio; Uhlemann, Anne-Catrin; Fidock, David A; Niles, Jacquin C; Avery, Vicky M; Charman, Susan A; Laleu, Benoît.
Afiliação
  • Okaniwa M; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Shibata A; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ochida A; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Akao Y; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
  • Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
  • Duffy S; Discovery Biology, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia.
  • Lucantoni L; Discovery Biology, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia.
  • Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.
  • Striepen J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Aguiar ACC; Sao Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100, São Carlos, São Paulo 13563-120, Brazil.
  • Sturm A; TropIQ Health Sciences, Transistorweg 5-C02, 6534 AT Nijmegen, The Netherlands.
  • Crespo B; Global Health, GlaxoSmithKline R&D, Tres Cantos, Madrid 28760, Spain.
  • Sanz LM; Global Health, GlaxoSmithKline R&D, Tres Cantos, Madrid 28760, Spain.
  • Churchyard A; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom.
  • Baum J; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom.
  • Pereira DB; Tropical Medicine Research Center of Rondonia, Av. Guaporé, 215, Porto Velho, Rondonia 76812-329, Brazil.
  • Guido RVC; Sao Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100, São Carlos, São Paulo 13563-120, Brazil.
  • Dechering KJ; TropIQ Health Sciences, Transistorweg 5-C02, 6534 AT Nijmegen, The Netherlands.
  • Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.
  • Uhlemann AC; University of Basel, 4002 Basel, Switzerland.
  • Fidock DA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Niles JC; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Avery VM; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
  • Charman SA; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.
  • Laleu B; Discovery Biology, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia.
ACS Infect Dis ; 7(6): 1680-1689, 2021 06 11.
Article em En | MEDLINE | ID: mdl-33929818
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_malaria / 3_neglected_diseases Assunto principal: Malária Falciparum / Aminoacil-tRNA Sintetases / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Revista: ACS Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_malaria / 3_neglected_diseases Assunto principal: Malária Falciparum / Aminoacil-tRNA Sintetases / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Revista: ACS Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão