Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group.
JCO Glob Oncol
; 7: 671-685, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33974442
ABSTRACT
PURPOSE:
To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS ANDMETHODS:
Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method.RESULTS:
Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR] 1.64), perirenal fat invasion (HR 2.02), and ≥ 2 metastatic organ sites (HR 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR 3.58).CONCLUSION:
Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Neoplasias Renais
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
JCO Glob Oncol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Uruguai