HLA-DP antigens are involved in the susceptibility to multiple sclerosis.
Tissue Antigens
; 31(5): 235-7, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-3400089
ABSTRACT
Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-DP
/
Antígenos HLA-D
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Tissue Antigens
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Dinamarca