Correlation between high hair cortisol level and intracranial aneurysm rupture.
Medicine (Baltimore)
; 100(22): e26193, 2021 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-34087887
ABSTRACT
ABSTRACT Measurement of cortisol in hair is a reliable method for determining long-term cortisol exposure reflecting chronic stress. Research using hair cortisol concentration has been limited to mainly cardiometabolic diseases. The association between hair cortisol concentration and aneurysmal rupture has not yet been studied. We aimed to investigate the relationship between the degree of chronic stress as measured by hair cortisol concentration and aneurysmal rupture.Sixty-eight patients diagnosed with intracranial aneurysms were included in this study (ruptured group, 30; unruptured group, 38). Hair cortisol was measured in 3-cm hair segments, reflecting roughly 3âmonths of hair growth. For a risk factor analysis, patient-specific factors and aneurysm-specific factors as well as hair cortisol concentration were investigated.Hair cortisol concentrations were significantly higher in the ruptured group than in the unruptured group (55.8â±â22.0âng/dL vs. 19.1â±â6.4âng/dL; Pâ<â.001). High hair cortisol concentration was found to be an independent risk factor for aneurysmal rupture (odds ratio [OR] 2.245, 95% confidence interval [CI] 1.825-2.753; Pâ=â.013). Additionally, a history of cerebrovascular disease was significantly associated with an increased risk of aneurysmal rupture (OR 1.577, 95% CI 1.099-2.262; Pâ=â.040).Based on our results, we suggest that chronic stress as measured by hair cortisol concentration could be an independent risk factor for intracranial aneurysmal rupture.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
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Aneurisma Intracraniano
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Aneurisma Roto
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Cabelo
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article