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Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir.
Gautam, Nagsen; McMillan, JoEllyn M; Kumar, Devendra; Bade, Aditya N; Pan, Qiaoyu; Kulkarni, Tanmay A; Li, Wenkuan; Sillman, Brady; Smith, Nathan A; Shetty, Bhagya L Dyavar; Szlachetka, Adam; Edagwa, Benson J; Gendelman, Howard E; Alnouti, Yazen.
Afiliação
  • Gautam N; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • McMillan JM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Kumar D; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Bade AN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Pan Q; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Kulkarni TA; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Li W; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Sillman B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Smith NA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Shetty BLD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Szlachetka A; Nebraska Nanomedicine Production Plant, University of Nebraska Medical Center, Omaha, NE, USA.
  • Edagwa BJ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Gendelman HE; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA. hegendel@unmc.edu.
  • Alnouti Y; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. hegendel@unmc.edu.
Nat Commun ; 12(1): 3453, 2021 06 08.
Article em En | MEDLINE | ID: mdl-34103484
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pró-Fármacos / Nanopartículas / Liberação Controlada de Fármacos / Lipídeos Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pró-Fármacos / Nanopartículas / Liberação Controlada de Fármacos / Lipídeos Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos