Your browser doesn't support javascript.
loading
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Drayman, Nir; DeMarco, Jennifer K; Jones, Krysten A; Azizi, Saara-Anne; Froggatt, Heather M; Tan, Kemin; Maltseva, Natalia Ivanovna; Chen, Siquan; Nicolaescu, Vlad; Dvorkin, Steve; Furlong, Kevin; Kathayat, Rahul S; Firpo, Mason R; Mastrodomenico, Vincent; Bruce, Emily A; Schmidt, Madaline M; Jedrzejczak, Robert; Muñoz-Alía, Miguel Á; Schuster, Brooke; Nair, Vishnu; Han, Kyu-Yeon; O'Brien, Amornrat; Tomatsidou, Anastasia; Meyer, Bjoern; Vignuzzi, Marco; Missiakas, Dominique; Botten, Jason W; Brooke, Christopher B; Lee, Hyun; Baker, Susan C; Mounce, Bryan C; Heaton, Nicholas S; Severson, William E; Palmer, Kenneth E; Dickinson, Bryan C; Joachimiak, Andrzej; Randall, Glenn; Tay, Savas.
Afiliação
  • Drayman N; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. tays@uchicago.edu nirdra@uchicago.edu.
  • DeMarco JK; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.
  • Jones KA; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Azizi SA; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
  • Froggatt HM; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Tan K; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
  • Maltseva NI; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.
  • Chen S; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Nicolaescu V; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Dvorkin S; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Furlong K; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.
  • Kathayat RS; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
  • Firpo MR; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Mastrodomenico V; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Bruce EA; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.
  • Schmidt MM; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
  • Jedrzejczak R; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Muñoz-Alía MÁ; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.
  • Schuster B; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Nair V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Han KY; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • O'Brien A; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Tomatsidou A; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
  • Meyer B; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
  • Vignuzzi M; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.
  • Missiakas D; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
  • Botten JW; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
  • Brooke CB; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.
  • Lee H; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Baker SC; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Mounce BC; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Heaton NS; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Severson WE; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Palmer KE; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.
  • Dickinson BC; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
  • Joachimiak A; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Randall G; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Tay S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Science ; 373(6557): 931-936, 2021 08 20.
Article em En | MEDLINE | ID: mdl-34285133
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 4_TD Problema de saúde: 4_pneumonia Assunto principal: Antivirais / Tiazóis / Inibidores de Cisteína Proteinase / Coronavirus Humano OC43 / Proteases 3C de Coronavírus / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 4_TD Problema de saúde: 4_pneumonia Assunto principal: Antivirais / Tiazóis / Inibidores de Cisteína Proteinase / Coronavirus Humano OC43 / Proteases 3C de Coronavírus / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article