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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.
Bruand, Marine; Barras, David; Mina, Marco; Ghisoni, Eleonora; Morotti, Matteo; Lanitis, Evripidis; Fahr, Noémie; Desbuisson, Mathieu; Grimm, Alizée; Zhang, Hualing; Chong, Chloe; Dagher, Julien; Chee, Sora; Tsianou, Theodora; Dorier, Julien; Stevenson, Brian J; Iseli, Christian; Ronet, Catherine; Bobisse, Sara; Genolet, Raphael; Walton, Josephine; Bassani-Sternberg, Michal; Kandalaft, Lana E; Ren, Bing; McNeish, Iain; Swisher, Elizabeth; Harari, Alexandre; Delorenzi, Mauro; Ciriello, Giovanni; Irving, Melita; Rusakiewicz, Sylvie; Foukas, Periklis G; Martinon, Fabio; Dangaj Laniti, Denarda; Coukos, George.
Afiliação
  • Bruand M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Barras D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Mina M; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland.
  • Ghisoni E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Morotti M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Lanitis E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Fahr N; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Desbuisson M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Grimm A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Zhang H; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Chong C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Dagher J; Institute of Pathology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Chee S; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA.
  • Tsianou T; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Dorier J; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Bioinformatics Competence Center, University of Lausanne, Lausanne, Switzerland.
  • Stevenson BJ; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Iseli C; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Ronet C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Bobisse S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Genolet R; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Walton J; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK.
  • Bassani-Sternberg M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Kandalaft LE; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Ren B; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA.
  • McNeish I; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK.
  • Swisher E; Department of Oncology, Washington University, Seattle, WA, USA.
  • Harari A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Delorenzi M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Ciriello G; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland.
  • Irving M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Rusakiewicz S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Foukas PG; 2nd Department of Pathology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Martinon F; Department of Biochemistry, UNIL, Lausanne, Switzerland.
  • Dangaj Laniti D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: denarda.dangaj@chuv.ch.
  • Coukos G; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: george.coukos@chuv.ch.
Cell Rep ; 36(3): 109412, 2021 07 20.
Article em En | MEDLINE | ID: mdl-34289354
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_endocrine_disorders / 6_malnutrition_nutritional_deficiencies / 6_ovary_cancer Assunto principal: Neoplasias Ovarianas / Proteína BRCA1 / Inflamação / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_endocrine_disorders / 6_malnutrition_nutritional_deficiencies / 6_ovary_cancer Assunto principal: Neoplasias Ovarianas / Proteína BRCA1 / Inflamação / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça