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Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice.
Zhang, Xue-Song; Yin, Yue Sandra; Wang, Jincheng; Battaglia, Thomas; Krautkramer, Kimberly; Li, Wei Vivian; Li, Jackie; Brown, Mark; Zhang, Meifan; Badri, Michelle H; Armstrong, Abigail J S; Strauch, Christopher M; Wang, Zeneng; Nemet, Ina; Altomare, Nicole; Devlin, Joseph C; He, Linchen; Morton, Jamie T; Chalk, John Alex; Needles, Kelly; Liao, Viviane; Mount, Julia; Li, Huilin; Ruggles, Kelly V; Bonneau, Richard A; Dominguez-Bello, Maria Gloria; Bäckhed, Fredrik; Hazen, Stanley L; Blaser, Martin J.
Afiliação
  • Zhang XS; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA. Electronic address: xuesong.zhang@rutgers.edu.
  • Yin YS; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Wang J; Department of Biochemistry and Microbiology, Rutgers University - New Brunswick, New Brunswick, NJ, USA.
  • Battaglia T; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Krautkramer K; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg 41345, Sweden.
  • Li WV; Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, NJ, USA.
  • Li J; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Brown M; Cardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Zhang M; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Badri MH; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA; New York University, Center for Data Science, New York, NY, USA.
  • Armstrong AJS; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
  • Strauch CM; Cardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
  • Wang Z; Cardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
  • Nemet I; Cardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
  • Altomare N; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
  • Devlin JC; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • He L; Department of Population Health, New York University Langone Medical Center, New York, NY, USA.
  • Morton JT; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
  • Chalk JA; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
  • Needles K; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
  • Liao V; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.
  • Mount J; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Li H; Department of Population Health, New York University Langone Medical Center, New York, NY, USA.
  • Ruggles KV; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA.
  • Bonneau RA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA; New York University, Center for Data Science, New York, NY, USA; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
  • Dominguez-Bello MG; Department of Biochemistry and Microbiology, Rutgers University - New Brunswick, New Brunswick, NJ, USA; Institute for Food, Nutrition and Health, Rutgers University - New Brunswick, New Brunswick, NJ, USA.
  • Bäckhed F; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg 41345, Sweden; Region västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden; Novo Nordisk Foundat
  • Hazen SL; Cardiovascular & Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44195, USA; Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Blaser MJ; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA; Human Microbiome Program, New York University Langone Medical Center, New York, NY, USA. Electronic address: martin.blaser@cabm.rutgers.edu.
Cell Host Microbe ; 29(8): 1249-1265.e9, 2021 Aug 11.
Article em En | MEDLINE | ID: mdl-34289377
Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_zoonosis Assunto principal: Ceco / Diabetes Mellitus Tipo 1 / Microbioma Gastrointestinal / Antibacterianos Limite: Animals Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_zoonosis Assunto principal: Ceco / Diabetes Mellitus Tipo 1 / Microbioma Gastrointestinal / Antibacterianos Limite: Animals Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article