Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect <i>In Vivo</i> in a Mouse Model in a Neutralization-Dependent Manner.

Amanat, Fatima; Strohmeier, Shirin; Lee, Wen-Hsin; Bangaru, Sandhya; Ward, Andrew B; Coughlan, Lynda; Krammer, Florian

Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner.

Amanat, Fatima; Strohmeier, Shirin; Lee, Wen-Hsin; Bangaru, Sandhya; Ward, Andrew B; Coughlan, Lynda; Krammer, Florian.

Afiliação

Amanat F; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Lee WH; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Bangaru S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Coughlan L; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Krammer F; University of Maryland School of Medicine, Maryland, USA.

mBio ; 12(4): e0100221, 2021 08 31.

Article em En | MEDLINE | ID: mdl-34311574

Assuntos

Enzima de Conversão de Angiotensina 2/imunologia; Anticorpos Monoclonais/imunologia; Anticorpos Monoclonais/farmacologia; Anticorpos Neutralizantes/imunologia; Receptores Virais/imunologia; Enzima de Conversão de Angiotensina 2/genética; Animais; Anticorpos Antivirais/imunologia; Anticorpos Antivirais/farmacologia; Chlorocebus aethiops; Feminino; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Testes de Neutralização; Ligação Proteica; Domínios Proteicos/imunologia; SARS-CoV-2/imunologia; Células Vero; Carga Viral; Tratamento Farmacológico da COVID-19

Palavras-chave

RBD; SARS-CoV-2; monoclonal antibodies

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Virais / Anticorpos Neutralizantes / Enzima de Conversão de Angiotensina 2 / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: MBio Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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