Open-label randomized control trial of hydroxychloroquine in patients with moderate to severe coronavirus disease 2019 infection.
Med J Armed Forces India
; 77: S305-S311, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-34334898
ABSTRACT
BACKGROUND:
At onset of coronavirus disease 2019 (COVID-19) pandemic, hydroxychloroquine (HCQ) was repurposed for treatment of patients based on reports that it had in vitro activity. The aim of this study was to find out if HCQ reduces number of days of hospitalization when given to patients with moderate to severe COVID-19 infections who require hospitalized care.METHODS:
This was an open-label randomized control trial of HCQ administered 400 mg twice on day 1, then 400 mg once daily from day 2 to day 5 in patients with moderate to severe COVID-19 infection. Assessment was not blinded. Standard of care was given to both arms.Primary outcome was number of days of hospitalization till discharge or death.RESULT:
One hundred ten patients (55 in each arm) were included. Mean age was 58 years. Baseline characteristics were well matched. There was no difference in the primary outcome (13.67 vs 13.89; p = 0.98). Number of deaths were more in HCQ arm (RR 1.81; 95% CI 1.13-2.93; p = 0.03). There was no difference in number of days on oxygen or normalization of oxygen saturation, number who needed ventilator, days to ventilator requirement and days on ventilator. Twenty-nine patients in control arm received remdesivir. When adjusted analysis was done after removal of these patients, there was no difference in primary or secondary outcomes. Number of deaths in adjusted analysis were not significant (RR 1.28; 95% CI 0.87-1.88; p = 0.37).CONCLUSION:
HCQ does not change the number of days of hospitalization when compared with control.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
4_TD
Problema de saúde:
1_doencas_transmissiveis
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2_enfermedades_transmissibles
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4_covid_19
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Med J Armed Forces India
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia