Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-&#954;B Pathway Stimulated by &#945;-Synuclein.

Zhong, Zhe; Chen, Weijie; Gao, Huan; Che, Ningning; Xu, Min; Yang, Lanqing; Zhang, Yingfang; Ye, Min

Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.

Zhong, Zhe; Chen, Weijie; Gao, Huan; Che, Ningning; Xu, Min; Yang, Lanqing; Zhang, Yingfang; Ye, Min.

Afiliação

Zhong Z; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Chen W; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Gao H; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Che N; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Xu M; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Yang L; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Zhang Y; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Ye M; Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China. yemin197001@sina.com.

Neurochem Res ; 46(11): 3050-3058, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34347266

Assuntos

Transplante de Microbiota Fecal/métodos; NF-kappa B/antagonistas & inibidores; Transtornos Parkinsonianos/prevenção & controle; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Receptor 4 Toll-Like/antagonistas & inibidores; alfa-Sinucleína/antagonistas & inibidores; Animais; Masculino; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Neuroproteção/fisiologia; Transtornos Parkinsonianos/induzido quimicamente; Transtornos Parkinsonianos/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptor 4 Toll-Like/metabolismo; alfa-Sinucleína/metabolismo

Palavras-chave

Gut microbiota; Parkinson's disease; TLR4/PI3K/AKT/NF-κB signaling; α-synuclein

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Transtornos Parkinsonianos / Proteínas Proto-Oncogênicas c-akt / Receptor 4 Toll-Like / Alfa-Sinucleína / Transplante de Microbiota Fecal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurochem Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google