Mitochondrial DNA Polymorphism in Zhejiang She Population Based on Next Generation Sequencing.
Fa Yi Xue Za Zhi
; 37(3): 358-365, 2021 Jun.
Article
em En, Zh
| MEDLINE
| ID: mdl-34379905
ABSTRACT
ABSTRACT Objective To study the genetic polymorphism of whole mitochondrial DNA ï¼mtDNAï¼ genomes in She population in Zhejiang and to explore the maternal genetic structure of the She population. Methods Whole mtDNA genomes of 231 unrelated individuals from She population in Zhejiang Province were sequenced. The number of mutations and population genetics parameters such as, the haplotype diversity ï¼HDï¼, discrimination power ï¼DPï¼, and random match probabilities ï¼RMPï¼ were analyzed. The mtDNA haplogroups of Zhejiang She population were classified, and the maternal genetic relationships between She and nine other Chinese populations were estimated. Results In 231 Zhejiang She samples, 8 507 mutations ï¼702 typesï¼ were observed and the samples were classified into 94 haplogroups. The HD, DP and RMP values were 0.998 6, 0.994 2 and 0.005 8, respectively. The lowest genetic differentiation degree ï¼Fst=0.006 89ï¼ was detected between Zhejiang She population and southern Han population. Principal component analysis ï¼PCAï¼ and median-joining network analysis showed that the genetic distance of Zhejiang She population with Guangxi Yao, Yunnan Dai and Southern Han populations was relatively close, but the population still had some unique genetic characteristics. Conclusion The whole mtDNA genomes are highly polymorphic in Zhejiang She population. The Zhejiang She population contains complex and diverse genetic components and has a relatively close maternal genetic relationship with Guangxi Yao, Yunnan Dai and Southern Han populations. Meanwhile, Zhejiang She population has kept its unique maternal genetic components.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Sequenciamento de Nucleotídeos em Larga Escala
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
/
Zh
Revista:
Fa Yi Xue Za Zhi
Assunto da revista:
JURISPRUDENCIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China