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Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease.
Ueno, Aito; Jijon, Humberto B; Peng, Richard; Sparksman, Steven; Mainoli, Barbara; Filyk, Alexis; Li, Yan; Wilson, Stephanie; Novak, Kerri; Panaccione, Remo; Hirota, Simon; Dufour, Antoine; Lu, Cathy; Beck, Paul L.
Afiliação
  • Ueno A; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Jijon HB; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Peng R; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Sparksman S; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Mainoli B; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Filyk A; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Li Y; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Wilson S; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Novak K; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Panaccione R; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Hirota S; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Dufour A; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Lu C; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Beck PL; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Inflamm Bowel Dis ; 28(2): 246-258, 2022 02 01.
Article em En | MEDLINE | ID: mdl-34428284
Intestinal strictures are thought to result from excessive deposition of extracellular matrix by activated mesenchymal cells. In this study, we provide evidence that supports a potential role of fibrocytes (bone marrow­derived mesenchymal precursors) in collagen deposition in Crohn's disease strictures. Inasmuch as fibrocyte numbers correlate with sonographic measures of bowel stiffness, fibrocyte numbers may predict the need for therapy escalation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Células-Tronco Mesenquimais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Células-Tronco Mesenquimais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá