Susceptibility of CTLA-4 -1661A/G polymorphism towards severity of rheumatic heart disease.
Indian Heart J
; 73(4): 511-515, 2021.
Article
em En
| MEDLINE
| ID: mdl-34474769
ABSTRACT
AIM:
Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease.METHODS:
In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms -1661A/G of CTLA-4.RESULTS:
Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 -1661G allele depleted as the disease progressed to CVL (p < 0.05). Patients in the age group of 31-45 years were significantly more susceptible (p < 0.046). Whereas, female patients were more susceptible than the male patients.CONCLUSION:
Our study suggests the risk associated with decreased frequency of CTLA-4 -1661G allele in the CVL group and in females.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Reumática
/
Cardiopatia Reumática
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Indian Heart J
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia