Tilting MYC toward cancer cell death.
Trends Cancer
; 7(11): 982-994, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34481764
ABSTRACT
MYC oncoprotein promotes cell proliferation and serves as the key driver in many human cancers; therefore, considerable effort has been expended to develop reliable pharmacological methods to suppress its expression or function. Despite impressive progress, MYC-targeting drugs have not reached the clinic. Recent advances suggest that within a limited expression range unique to each tumor, MYC oncoprotein can have a paradoxical, proapoptotic function. Here we introduce a counterintuitive idea that modestly and transiently elevating MYC levels could aid chemotherapy-induced apoptosis and thus benefit the patients as much, if not more than MYC inhibition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas c-myc
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos